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In general, the most frequently reported symptoms in cirrhosis include: pain (prevalence range 3079%), breathlessness (2088%), muscle cramps (5668%), sleep disturbance (insomnia 2677%, daytime sleepiness 29.571%), psychological symptoms (depression 4.564%, anxiety 1445%), and erectile dysfunction (5393%) in men (3, 4)

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Altered sciatic nerve fiber morphology and endoneural microvessels in mouse models relevant for obesity, peripheral diabetic polyneuropathy, and the metabolic syndrome